He has produced and remixed for some of hip hop's and music's most respected and well-known artists such as Alicia Keys, Amy Winehouse, Drake, Eminem, Big Pun, Fat Joe, Krs One, Rakim, Big Daddy Kane, and many more. Domingo is one of the most prominent Hip Hop producers to ever come from East New York, Brooklyn.

He has been producing professionally since the age of 17 when hip hop legend/producer Marley Marl took him under his production company “The House of Hits” and mentored Domingo to be who he is today. In 1997 with the release of the critically acclaimed KRS-One album I Got Next, Domingo accomplished the accolades of gaining his first Gold record from the successful sales of the album. The album went on to sell well over 650,000 copies worldwide. In 1998 Domingo had further accomplishment of gaining his first Platinum record from the sales of the Big Pun Capital Punishment album.

In the same year, Domingo was nominated for both American and Latin Grammys for his production work on the Big Pun album. This classic album sold 2.3 Million copies worldwide. Domingo released his first proper studio album in 1999, titled Behind The Doors Of The 13th Floor. The album featured Eminem, KRS-One, MC Shan, and others. In the year 2003 Domingo released his 2nd album The Difference. That album featured the likes of The Beatnuts, Dilated Peoples, High N Mighty, and others. The Difference had the Domingo produced song by Krs One entitled Clear Em Out which sparked the "beef" between Krs One and St Louis rapper Nelly. In 2007 Domingo released his 3rd studio album, The Most Underrated. It features Big Daddy Kane, Joell Ortiz, Canibus, Termanology, Immortal Technique, The Beatnuts, Kool G Rap, Brother Ali, and others. Domingo resurfaced with a new album in 2014 entitled Same Game New Rules. The album features Kool G Rap, KRS-One, R.A. the Rugged Man, Sean Price, M.O.P., Prodigy, Chris Rivers (Big Pun's son), Hell Razah, Ras Kass, AZ, Necro, Action Bronson, Sadat X, Rahzel and more.

Also, in December 2014, Domingo released an Ep dedicated to the memory of rapper Big Pun entitled Bronx Legends Never Die. The Ep was highly regarded as a classic ep. In 2015 it was a busy year for Domingo as he took the reigns as a promoter and created the company That's Hip Hop LLC and put on 2 sold-out concerts in the city of Pittsburgh, PA. He also won an ASCAP Rhythm & Blues award for his participation in the Drake song All ...